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Treatment-Resistant Depression

If standard depression treatments aren’t working, you may have treatment-resistant depression. TRD is an often misunderstood condition that can be frustrating and difficult to deal with.

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What is Treatment-Resistant Depression?

Treatment-resistant depression (TRD) is a type of major depressive disorder (MDD) that does not respond well to traditional forms of treatment, such as antidepressant medications and psychotherapy. People with TRD may experience severe symptoms that can interfere with their ability to function in day-to-day life.

Signs of Treatment-Resistant Depression

The signs and symptoms of TRD can vary from person to person and are comparable to the common symptoms of major depressive disorder (MDD). Distinguishing between the two will require a comprehensive evaluation by a mental health professional.

Common symptoms of TRD include:

  • Persistent sadness or feelings of emptiness
  • Angry outbursts, irritability, or frustration over small matters
  • Loss of interest or pleasure in activities you once enjoyed
  • Sleep disturbances, including insomnia or sleeping too much
  • Fatigue or decreased energy
  • Changes in appetite or weight
  • Anxiety, restlessness, or agitation
  • Slowed thinking, speaking, or body movements
  • Feelings of worthlessness or guilt
  • Difficulty concentrating, making decisions, or remembering things
  • Frequent thoughts of death or suicide

Ultimately, you will need the guidance of a specialist to make an accurate diagnosis but if you have been living with depression and not seeing the results you want from treatment, it’s important to consult with your doctor to see if you have Treatment-Resistant Depression.

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How is TRD diagnosed?

There is no one specific test or set of criteria used to diagnose TRD. A diagnosis may be made based on a comprehensive assessment that includes a review of your medical history, family history, symptoms, and other factors. Your doctor may also perform a physical exam and order laboratory tests to rule out other conditions that may be causing your symptoms.

What causes TRD?

The exact cause of TRD is not fully understood, but it is thought to be caused by a combination of physical, psychological, and social factors. Physical factors that may contribute to TRD include changes in brain chemistry or structure, hormonal imbalances, and health conditions like thyroid disorders or sleep disorders. Psychological factors that may contribute to TRD include negative thinking patterns, trauma, and stress. Social factors that may contribute to TRD include isolation, poverty, and chronic stress.

How common is TRD?

TRD is a relatively common condition. It is estimated that about one in three people with major depressive disorder (MDD) will not respond to traditional forms of treatment.

Can TRD be cured?

TRD cannot be cured, but it is a treatable condition. With proper treatment, most people with TRD can manage their symptoms and live relatively normal lives.

If you are experiencing signs and symptoms of TRD, book an appointment today.